"Universal
remedy, fountain of youth, worldwide media with their sensetionalist emphasis
made their covers with. So from week to week, DHEA is a new viagra
(TM), a synthetic hormon, a natural hormon... Lawsuits have already begun with wrong arguments,
glossing dangers -especially economic- or immoral immortality...
In handypills lands, vitamins injection
and other synthetic anti-oxydants, instead
of nutritionnal hygiene and synergic natural complements -however indispensable
kees for anti-ageing- DHEA could appear only as one more molecule...
With this sudden notoriety within
the general pubic, confusion and misunderstanding risk about DHEA and its
qualities, is maximum...
AT THE POINT
OF VERIFYING
THE AGEING ENDOCRINIAN THEORY
PPublished in
the minutes of the American Academy of Science, DHEage,
the first clinic study on DHEA (over 280 old
persons after one year everyday treatment- made by the Professor Etienne-Emile
BAULIEU (INSERM) and Professor F. FORETTE (Gerontology Foundation), in
partnership with twenty French searchers, is in the point of verifying
the basis hypothesis of the ageing endocrinian theory : a
lot of degenerating deseases and functionnal deteriorations result on drop
of some hormons production. For the first
time, a normalisation indeed an ageing reversal
is considered, made possible by hormonal addition.
La DHEA has nevertheless already an history
: - Actually, since 1931 the Germain A. BUTERNANDT
(the Chimics Nobel Prize, 1939) isolated chimically in urines, under its
free shape, the DHEA. - In 1958, the French Max Fernand JAYLE, Professor
of biochimics at Paris Medecine University, shows the decrease of DHEA
rates during the ageing (the professor Etienne-Emile
BAULIEU was one of his closest pupils) - In the seventies, course of international
studies allow considering potentials offects of DHEA without any definetly
prouved action on mankind. - It must be wait until 1994 when the professor
Samuel YEN publishes the first positive tests on mankind.
The DHEA or deshydroepiandosterone(chimical
of steroïd hormons) is anti-ageing hormon made from adrenal glands
(it was, in 1960, the EE BAULIEU discovery).
It is the prevalent
hormon of our body. Doctor W. REGELSON calls
it "hormons mother" because our body turns
it just into the hormon shape it needs.
It is an essential component on most of physiological
functions. The system uses it especially on making sexual hormons as Testosterone,
Oestrogen and Progesteron. Indirectly, adding DHEA may rise the IGF-1
level (de result of the transformation process of growth hormon), which
constitutes one of plausible explanations of its health benefits. DHEA
circulates in the body principaly under water-soluble shape, sulphate of
DHEA (DHEA-S) that we can easily measure by tests (salivary, urinary, and
better, blood tests).
DHEA has normaly a sufficient lvel on people under
thirty that should take it only if the analysis reveal a lack or if their
therapist recommends it. At fourty, spectacular
"mark of age", DHEA level is no more than
half of optimum level, and at 75 it has decreased of 80 to 90%. Circulating rates fall from 5 to 0 % last
year of life. This loss of DHEA with ageing is attributed
to 17/20 desmolase and 17/20 lyase enzyme which synthesis, reduced meanwhile
we get older, cannot be regenerated or replaced. This phenomenon can be
observed through a microscope at reticulated zone of adrenal where DHEA
is produced.
As per Doctor WHITAKER, this decline goes with
organic dysfonction : a lowed
rate of DHEA represents the common factor of all the degenerating phenomena
and DHEA would constitute an objectiv and measurable approch of what we
could call today "Fountain of Youth".
Drop of DHEA
rate is accelerated by, - taking diuretics, - lack
of anti-oxydants (vitamin C, vitamin
E, selenium, magnesium, zinc or cholestérol), - stresses
(caused by operations or of psychic origin : latent depression, indecision,
lack of initiative). DHEA is indeed on reverse relation to production
of corticosteroids hormons that are produced by adrenals, and also by the
brain, we must not forget ! -
by reaction to stresses. Now those
appear as essential factor on the DHEA rate decline,
as far back as thirty, it goes with
an increased sensitiveness to diseases, as well as acceleration of ageing.
Like this; the more stress we have, the more
DHEA decreases. This drop is partially reversible about human being from
which the idea of supplementation of this element.
Supplementation
of DHEA can begin between 35 and 45 for individuals particularly tired,
stressed or immunodepressed.
LThe optimal dosage varies for each person.
Way of life, metabolism, and medical records
have an influence on the use of supplement.
In general, is recommended to women (not pregnant or nursing)
to take 25 mg per day and men 50 mg. Taking supplement of these
DHEA dosages during a variable time, it is possible to restore optimal
rates of serum measured between 25 and 30 years old.
Dr Whitaker, verifiying the whole
proved characteristics of DHEA and no toxicity in small quantity (50mg/24h)
maintains that it is now impossible to imagine
his medical activity without this hormon in his everyday therapeutics.
Extra DHEA, under adviced doses, is for the
moment remarkably safety and has produced almost no secondary effect.
- Less
and even delays on ageing effects :
more muscular mass, rejuvenation of skin, protection of neurologic functions,
significativ improvment of cognifiv phenomena (Alzheimer and Parkinson
disease).
(Dr Kennet BONNET, searcher at psychiatric
department at University of New-York has reported the exceptional characteristics
of DHEA on persons having short or long term troubles of memory).
- High
and quick improvment of energy, vitality and libido level (DHEA
precusor of sexual hormons), discernible after only a few weeks on 82 %
of women and 67 % of men (from a study made by the University of San Diego,
California), - A better
response on stress (comparativ group
study) and better quality of
sleep, - An increase
of immune resistance (virus infections
from common cold to herpès) and HIV (stimulation of lymphocytes
T by increae of Interleukine 2 (IL2), fight against multiple sclerosis).
- An antidiabetic
action.
Arthur Schwartz, searcher at Temple
University of Philadelphia proved that DHEA blocked G6PD enzyme, preventing
cancerous cellular division from development and adipose cells from proliferation.
In his opinion, DHEA is proved to be a fundamental anti obesity agent.
In fact, DHEA appears as the first substance tested in laboratory able
to provoque an actual fatty melting instead of a weight loss due globally
to muscular tissues melting or liquid losses, and this without any change
of food habits. DHEA enables muscular mass, calories being simply
converted into heath instead of being fat stocked. In january 1994, Dr
Robert Atkins maintained that DHEA had all chances of becoming an important
diabetics treatment.
- The peculiar antiatherosclerosis
qualities (cardiovascular protection)
A study of Dr Elisabeth Barret-Conner
allowed to observe a reduction of cardiovascular diseases of 48 % and a
reduction of 36 % of death rate from other affections by taking everyday
DHEA. She concluded that DHEA seemed to protect very soon all serious forms
of death. "It was reported that high rates of DHEA and
its sulfate would protect from cardiovascular attacks, reduce LDL cholesterol
and atherom patches, adhesion of platelets, excess of macrophage and proliferation
of cells arterial walls (intima)" Kay-Tedd Khaw, Cambridge (UK).
- « Bony effects recorded (bony density
and osteocalcine) bode practical interest of DHEA from prevention
and treatment of osteoporosis : improvement
of calcium absorption by acting on vitamin D metabolism, so decrease of
bony loss" P. DIAMOND
- Modulation
of other hormonal functions, that can contribute to reduce troubles associated
to male and female menopause.
- Reduction of systemic lupus erythema.
- Slowing up some forms of cancers.
(DHEA is a natural substance normaly
present in the organisme, necessary for growth and cell multiplication
control. It was demonstrated that persons with brest cancer had a DHEA
rate specially low) One of the 40000 studies published on DHEA
shows that women which blood rate of DHEA
is more than 10 % lower than normal average rate of their group of age
died from mulmonary cancer instead fo those which DHEA rate was better
than average didn't have any tumour phenomenon.
DHEA,
natural hormon, is used by the body according to its needs, that's why
it's reasonably possible to think that complements
to dosages recommanded are not toxic and are in any case much more sure
than dose of hormons or synthetic steroïds. Activ on multiple fields, DHEA is going to
prouve its total innocousness, what cannot claim synthetic hormons (remaking
no synergic) classed wrongly byr reducing minds in the same category than
DHEA.
DHEA is produced in laboratory from saponine
plant origin named Diosgenine. Human body doesn't have enough enzymes to
make this conversion. The allegations about
products stimulating "naturally" the production of DHEA are devoid of any
foundation.
How is it possible so to find or make it naturally
if the organism does'nt make it anymore ?
Several sources and helps :
- Plant hormons :
To produce DHEA,
it is necessary to extract many others génine, peptides and enzyms,
to carry on an efficient synthesis of the hormon. Although
other sources of plant steroïds are easily available to reach these
aims - as soja seeds, agave and yucca - wild yam constitutes the most concentrated
source known and used. Among those important uses of wild yam root,
we can mention precursors and phytopharmacomimetrics substances of DHEA.
Wild yams DIOSCOREA could so be used as precursors of DHEA because the
sterols they keep naturally are transformed to lead to hormon.
- Squalene (in shark
liver oil) - of which good effects on health are rather closes to DHEA
and being speciallay a tremendous anti-oxydant.
In fact squalene,
-present also in olive oil - is a precursor
of DHEA. To be activ, it must got first
a sulfurization (sulfur addition). This operation brings in the mésencéphale,
hypophysis and thymus. DHEA paralyses the enzyme glucose-6-phosphate deshydrogenase,
very important for agressiv dynamics in the cancerous cell. For that case,
DHEA prevents from transforming normal cells
into malignant cells caused by carcinogenic virus.
Blood rate of DHEA can be dosed. It has to exceed 3,3 mg/litre. It goes
sometimes under 0,1 mg/litre on people having cancer...
- Homeopathy has some results
restoring more a balance instead of stimulating. So organotherapy (adrenals 4CH to reactivate
exhausted adrenals) or more pineal 4CH...
Marketing of
DHEA hormon is not yet allowed in France (question of reimbursing by Social
Security is one of evident brake) in opposite to United States where it
is sold since 1992 as food complement
- without prescription - in
all type of shops and with several brands very often created for this circumstance...
It is easy for Professor BAULIEU to speak about
doutful amount
of some american DHEA (easily available on internet), and forgetting that
in Europe, wellknown and serious
laboratories that produce DHEA and supply a lot of bio pharmacies.
Natural product not
patentable, not profitable (no investment
return for market research), we can understand why pharmaceutical industry
shows that same half-heartedness that on many other natural matters (amino
acids, vitamins, minerals). It is all a « system »
that is involved ; pursuit of of profit and industrial protectionnism opposed
to research of welfare, health, balance and prevention.
Particular Thanks to Dr Dominique
Rueff and to Laure Pouliquen
BIBLIOGRAPHY
-
Dr Dominique RUEFF & Dr Maurice NAHON « La Bible Anti-Age » - Dr Dominique RUEFF & Dr
Maurice NAHON « Hormones vegetales naturelles » - DHEA « neurostéroïde,
précurseur hormonal » (extrait du journal de clinique endocrinologique
et du métabolisme. - Dr Joseph LEVY « Revolution
silencieuse de la medecine » - Dr Joseph LEVY « Dictionnaire
de la Medecine Ecologique » - Dr Thierry HERTHOGHE &
Dr Jules NABET « Comment rester jeune plus longtemps » - Laure POULIQUEN, Naturothérapeuthe-Nutritionniste,
[http://site.voila.fr/ANTI-VIEILLISSEMENT]
- Science & Avenir juin2000
(Sandrine CABUT) - François GIRON (Le
Point Janvier 1995), - Philippe PERRUCHON- Naturothérapeute-Kinésiologue
SOURCES
-KALIMI,
REGELSON, The Biologic Role of DHEA New York. Walter de Gruyter 1990 -KALIMI, REGELSON, DHEA, The
Multifunctional Steroid Effects on tje CNS, Cell proliferation, metabolic
and vascular, clinical and others effects. Ann New York Acad Sci 719 :
564-575. 1994 - MORALES, NOLAN, NELSON, YEN,
Effect of replacement close of DHEA in men and women of advancing age.
J.Clin Endocrinol Metab 78 : 1360-1367. 1994 - MAJEWSKA , Neuronal actions
of DHEA : Possivble roles in brain development, aging, memory, and affects.
Ann New York Acad Sci 774 : 11-120, 1995 - WOLLKOWITZ, Antidepressant
and cognition-enhancing effects of DHEA in major depression. Ann NewYork
Acad Sci 774 337-339. 1995 - YEN, MORALES, KHORRAM : Replacement
of DHEA in aging men and women. Ann New-york Sci 774 : 128-142 1995 - ARANEO, DOWELL, WOODS, DAYNES,
JUDD, EVANS. DHEA as an effective vaccine adjuvant in elderly humans. Ann
NY Acad Sci 774 :232-248 1995 - ROBERTS, FAUBLE, Oral DHEA
in multiple sclerosis : results of a phaseone, open study In : The Biological
Role of DHEA, pp 81-93 Walter de Gruyster Berlin 1990 - VAN VOLLENHAVEN, ENGELMAN,
Mc GUIRE An open study of DHEA in systemic lupus erythematosis, Arthritis-
Rheum 37 1305-1310
1994
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